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. 2019 Nov 26;13:1256. doi: 10.3389/fnins.2019.01256

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Copyright © 2019 Amantea, Petrelli, Greco, Tassorelli, Corasaniti, Tonin and Bagetta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Systemic administration of a single dose of azithromycin exerts neuroprotection up to 7 days after reperfusion in rats subjected to 2 h MCAo. (A) Ischemic area, (B) infarct and edema volumes, (C) neurological deficit and (D) body weight of rats subjected to 2 h MCAo followed by 7 days of reperfusion. Rats were injected i.p. with vehicle (0.9% NaCl) or azithromycin (AZM, 150 mg/kg) upon reperfusion. Data are expressed as mean ± SEM of four independent experiments (n = 4 rats per experimental group); ^∗∗∗P < 0.001 and ^∗P < 0.05 vs. corresponding vehicle (two-way ANOVA followed by Bonferroni post hoc test); ^#P < 0.05 and ^##P < 0.01 vs. corresponding vehicle (ANOVA for repeated measures followed by Bonferroni post-test).