FIGURE 7.

A single dose of azithromycin administered 4.5 h after MCAo reduces ischemic brain damage measured 24 h after the insult. (A) Infarct area and (B) volumes of infarct and edema of rats subjected to 4.5 h of MCAo followed by 19.5 h of reperfusion. Rats were injected i.p. with vehicle (0.9% NaCl) or azithromycin (AZM, 150 mg/kg) upon reperfusion. Data are expressed as mean ± SEM of four independent experiments (n = 4 rats per experimental group); ^∗∗∗P < 0.001 vs. vehicle (two-way ANOVA followed by Bonferroni post hoc test).