TABLE 2.

Studies demonstrating exosomes diagnosis and treatment of heart diseases.

Functional component	Disease	Species	References
miR-126 and miR-26	CAD	Humans	Zampetaki et al., 2010
miR-223, miR-29b RNU6-2	CV risk in smokers	Humans	Badrnya et al., 2017
miR-1, miR-21, miR-133, miR-146a, miR-208b, miR-499	Ischemic heart disease	porcine	Deddens et al., 2016
Apolipoprotein C-III, Apolipoprotein D, complement C1q subcomponent A, platelet glycoprotein 1b alpha chain, platelet basic protein	Ischemic Heart Disease	Humans	Cheow et al., 2016
miR-194, miR-34	Heart failure post-MI	Humans	Matsumoto et al., 2013
miR-146a	Peripartum cardiomyopathy	Humans	Halkein et al., 2013
miR-17, miR-197, miR-509-5p, miR-92a, miR-320a,	Metabolic syndrome	Humans	Karolina et al., 2012
miR-1, miR-133a, miR-208	Acute coronary Syndrome	Humans	Kuwabara et al., 2011
CD144 EMP	Coronary heart disease	Humans	Nozaki et al., 2009
Endothelial microparticle	Cardiovascular mortality in end stage renal failure	Humans	Amabile et al., 2010
Endothelial microparticle	Preeclampsia	Humans	González-Quintero et al., 2003
miR-126 and MiR-199a	Cardiovascular events	Humans	Jansen et al., 2014
CCL2, CCL7 and IL6	Cardiac inflammation post-MI	Mouse Humans	Loyer et al., 2018
Inflammatory and immunoglobulin class proteins	Transplant rejection	Humans	Kennel et al., 2018
Cardiac bridging integrator 1	Heart failure	Humans	Nikolova et al., 2018
miR-92b-5p	Dilated cardiomyopathy	Humans	Wu et al., 2018, p. 199
miR-223	Sepsis (microbial and non-microbial)	Mouse	Wang et al., 2015