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. 2019 Dec 3;10:2777. doi: 10.3389/fimmu.2019.02777

Figure 2.

Figure 2

Colon polyps in 5CreCAT mice. (A) Representative colon of an aged 5CreCAT mouse; arrows point to individual polyps. (B) Number of colon polyps from 8 male and 10 female 5CreCAT mice. (C–H) Serially cut 5 μm sections of FFPE-fixed colons from 5.5 months old mice were used for histology and immunohistochemistry; arrows point to adenomatous polyps and arrow heads to lymphoid aggregates. Student's t-test did not show any significance. (C) Jelly roll of a representative 5CreCAT colon, H&E 16X. (D) Adenomatous polyp of the same, stained for ß-catenin, 50X. (E) Border of transformed and hyperplastic crypts in the same adenoma, stained for nuclear ß-catenin 200X. (F) Rare small bowel adenoma; H&E 50X. (G) the same adenoma, stained for ß-catenin of 50X. (H) Border of transformed and hyperplastic crypts in the same adenoma, stained for ß-catenin 200X. (I) 5CreCAT mouse skin tumor H&E stain 100X; arrows show nodules invading the dermis. (J) the same skin tumor mMCP5 stain 100X; arrows point to MCs. (K) the same image 400X.