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. 2019 Nov 22;10:1132. doi: 10.3389/fgene.2019.01132

Figure 4.

Figure 4

Dependence of f-SatIII content in the DNA of patients on antipsychotic therapy and the integrative PANSS score. (A) Change in f-SatIII content in the SZ(M-) patients DNA after a month of antipsychotics therapy. For 93 patients not taking antipsychotics at the admission to the hospital DNA was isolated from leukocytes twice—before the treatment and upon discharge from the hospital. The first test data (sample 1) are ranked for clarity. A significant increase in the f-SatIII DNA content after the treatment was found for samples with initially low f-SatIII content. F-SatIII content reduction was observed for samples with initially high repeat content. (B) The dependence of the integrative PANSS score on the f-SatIII content in the SZ cohort. Linear regression showed a weak negative correlation between f-SatIII and PANSS. In the subgroups of patients with low f-SatIII content (I-subgroup with f-SatIII less than 20 pg/ng DNA) the PANSS results was significantly higher than in the patients with high f-SatIII content (II-subgroup, more than 20 pg/ng). The figure on the right shows the corresponding distributions and statistics.