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. 2019 Nov 22;10:1132. doi: 10.3389/fgene.2019.01132

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Copyright © 2019 Ershova, Agafonova, Zakharova, Bravve, Jestkova, Golimbet, Lezheiko, Morozova, Martynov, Veiko, Umriukhin, Kostyuk, Kutsev, Veiko and Kostyuk

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A hypothetical scheme illustrating the changes in the f-SatIII content during human life. HC: healthy individual. During the aging the content of f-SatIII usually increases. Patient SZ-1: deletion of the genome regions containing f-SatIII (low repeat content). During the aging the content of f-SatIII increases. Patient SZ-2: normal f-SatIII content in the genome; during the aging the content of the repeat decreases. Patient SZ-3 [H-SZ (M+)]: normal f-SatIII content in the genome at the beginning of embryogenesis. Hypoxia and OCs stimulate an increase in repeat content. During the aging the content of the repeat decreases.