Table 3. Genetic Scores for Lipid Levels and Coronary Artery Calcium.
| Covariates (Genetic Scores)a | Coronary Artery Calcium Score Greater Than 0 (n = 4837) | loge-Transformed Coronary Artery Calcium Scoreb (n = 4837) | ||
|---|---|---|---|---|
| Odds Ratioc (95% CI) | P Value | Effect Size (95% CI) | P Value | |
| non–HDL-C | 2.04 (1.70-2.44) | 5.3 × 10−15 | 0.70 (0.53-0.87) | 1.0 × 10−15 |
| HDL-C | 2.05 (1.70-2.48) | 4.2 × 10−14 | 0.67 (0.50-0.85) | 1.4 × 10−13 |
| HDL-C and triglycerides | 2.07 (1.69-2.55) | 3.9 × 10−12 | 0.70 (0.50-0.90) | 3.5 × 10−12 |
| LDL-C | 2.06 (1.18-3.60) | .01 | 0.80 (0.27-1.33) | .003 |
| LDL-C | 1.91 (1.60-2.27) | 1.4 × 10−13 | 0.62 (0.46-0.79) | 7.6 × 10−14 |
| HDL-C and triglycerides | 1.84 (1.54-2.19) | 9.8 × 10−12 | 0.58 (0.41-0.74) | 1.4 × 10−11 |
| Non–HDL-C | 0.99 (0.58-1.69) | .97 | –0.10 (–0.61 to 0.41) | .70 |
| HDL-C | 0.87 (0.76-0.99) | .04 | –0.22 (–0.35 to –0.09) | .001 |
| LDL-C and triglycerides | 1.01 (0.86-1.18) | .91 | –0.09 (–0.23 to 0.06) | .26 |
| Non–HDL-C and triglycerides | 1.01 (0.87-1.18) | .88 | –0.07 (–0.20 to 0.07) | .34 |
| Triglycerides | 1.43 (1.18-1.74) | 3.2 × 10−4 | 0.37 (0.18-0.56) | 1.4 × 10−4 |
| LDL-C and HDL-C | 1.26 (1.00-1.57) | .047 | 0.18 (–0.04 to 0.39) | .10 |
| Non–HDL-C and HDL-C | 0.97 (0.76-1.24) | .83 | –0.07 (–0.3 to 0.17) | .57 |
Abbreviations: HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.
SI conversion factor: To convert HDL-C, non–HDL-C, and LDL-C to mmol/L, multiply by 0.0259.
a
In all models, age, age2, and sex were included as covariates, in addition to the genetic scores.
b
loge(CAC score + 1).
c
Odds ratios and linear regression coefficients are scaled to correspond to a 1-SD increase in the respective cholesterol trait or doubling of triglyceride levels. For non–HDL-C, LDL-C, and HDL-C, this corresponds to 37 mg/dL (0.97 mmol/L), 37 mg/dL (0.87 mmol/L), and 15 mg/dL (0.38 mmol/L), respectively.