. 2019 Nov 21;6(1):75–82. doi: 10.1001/jamaoncol.2019.4320

Table 4. Distribution of Patients by Highest-Grade Adverse Event by Specific Adverse Event Term Occurring More Than 1 Year From Completion of Partial Breast Reirradiation^a.

System Organ Class or Term	Adverse Event Grade, No.
System Organ Class or Term	1	2	3	4	5
Infections and infestations
Total	0	1	1	0	0
Breast infection	0	0	1	0	0
Musculoskeletal and connective tissue disorders
Total	17	5	1	0	0
Fibrosis deep connective tissue	9	3	1	0	0
Reproductive system and breast disorders
Total	9	6	3	0	0
Breast atrophy	4	5	1	0	0
Breast pain	9	1	1	0	0
Other^b	2	0	1	0	0
Skin and subcutaneous tissue disorders
Total	12	9	1	0	0
Skin induration	4	4	1	0	0
Overall highest grade, No. (%)	14 (24.6)	15 (26.3)	4 (7.0)	0	0

^{^a}

Adverse events were graded with Common Terminology Criteria for Adverse Events, version 4. One patient died before 1 year; thus, 57 patients were evaluated.

^{^b}

Breast volume loss.

Table 4. Distribution of Patients by Highest-Grade Adverse Event by Specific Adverse Event Term Occurring More Than 1 Year From Completion of Partial Breast Reirradiationa.

Table 4. Distribution of Patients by Highest-Grade Adverse Event by Specific Adverse Event Term Occurring More Than 1 Year From Completion of Partial Breast Reirradiation^a.