Figure. Myeloimmunoablative Conditioning and Event-Free and Overall Survival.

A. Myeloimmunoablative conditioning regimen and supportive care. B, Probability of overall survival before and after health-related quality of life and processing speed. The probability of event-free survival (event defined as death or recurrent sickle cell disease symptoms) and overall survival in 19 enrolled patients following familial haploidentical stem cell transplant using donor CD34+ enrichment and mononuclear cell addback determined by the Kaplan-Meier product limit method. HSCT indicates haploidentical stem cell transplant; Max, maximum; and SCT, stem cell transplant.

^aPatients who underwent stem cell transplant received hydroxyurea and azathioprine starting day –59 to day –11, fludarabine on days −17, −16, −15, −14, and −13; busulfan twice daily on days −12, −11, −10, and −9; thiotepa on day −8; cyclophosphamide on days −7, −6, −5, and −4; total lymphocyte irradiation on day −2; and rabbit antithymocyte globulin on day −5,−4,−3, and −2.