Table. Meta-regression From Frequentist and Bayesian Models.
No. of Studies in Bayesian/Frequentist Analyses (n = 34/n = 18) | Covariate | Frequentist Model | Bayesian Model | ||
---|---|---|---|---|---|
OR (95% CI) | P Valuea | OR (95% CrI) | Probability Relative OR ≤ 1.00b | ||
Diagnosis | |||||
6/3 | AMD | 1.01 (0.46-2.20) | 1 [Reference] | 0.98 (0.33-3.41) | 1 [Reference] |
15/11 | DME | 1.68 (1.01-2.77) | .17 | 1.75 (0.94-3.85) | 0.15 |
13/4 | RVO | 0.45 (0.09-2.17) | .72 | 0.30 (0.03-2.25) | 0.82 |
No. of injections | |||||
33/17 | Per 1 more | 1.12 (1.04-1.22) | .005 | 1.06 (0.98-1.15) | 0.06 |
Drug | |||||
18/6 | Ranibizumab | 1.44 (0.72-2.87) | 1 [Reference] | 1.75 (0.74-4.82) | 1 [Reference] |
6/1 | Bevacizumab | 0.66 (0.03-14.6) | .65 | 24.4 (0.10-∞) | 0.24 |
3/1 | Pegaptanib sodium | 1.00 (0.39-2.21) | .64 | 1.03 (0.21-4.97) | 0.74 |
6/10 | Aflibercept | 1.47 (0.79-2.72) | .56 | 1.46 (0.61-3.23) | 0.62 |
Follow-up, mo | |||||
14/5 | 6 (6-8) | 0.65 (0.16-2.66) | 1 [Reference] | 0.82 (0.15-6.53) | 1 [Reference] |
15/8 | 12 (11-12) | 1.02 (0.54-1.92) | .83 | 1.07 (0.51-2.46) | 0.41 |
5/5 | 24 (23-24) | 1.89 (1.06-3.36) | .17 | 2.07 (1.06-4.49) | 0.21 |
Previous cardiovascular disease | |||||
15/7 | No | 1.12 (0.70-2.06) | 1 [Reference] | 1.23 (0.52-3.22) | 1 [Reference] |
18/11 | Yes | 2.12 (0.56-8.08) | .14 | 1.50 (0.41-4.72) | 0.24 |
Abbreviation: OR, odds ratio.
Calculated for the comparison of the ORs of death in the subgroup compared with that in the reference category.
Indicates probability that the relative OR for the category is more than 1.00 compared with the reference category.