. 2019 Dec 4;5(2):147–155. doi: 10.1001/jamacardio.2019.4528

Table 4. Risk Analysis for Changes in CPC Counts During Exercise for Composite Event Rate of Cardiovascular Death and Myocardial Infarction.

Variable	C Statistic (95% CI)	Change in C Statistic (95% CI)	Continuous NRI (95% CI)	IDI (95% CI)
Model^a	0.72 (0.62-0.80)	NA	NA	NA
Model plus CD34⁺ change	0.76 (0.69-0.86)	0.04 (0.01-0.11)	0.50 (0.21-0.71)	0.03 (0.01-0.08)
Model plus CD34⁺/CXCR4⁺ change	0.77 (0.71-0.91)	0.06 (0.02-0.13)	0.54 (0.28-0.79)	0.04 (0.01-0.11)

Abbreviations: CPC, circulating progenitor cell; IDI, integrative discrimination improvement; NA, not applicable; NRI, net reclassification index.

^{^a}

The model includes age; sex; race; smoking history; body mass index (calculated as weight in kilograms divided by height in meters squared); history of heart failure, hypertension, dyslipidemia, and diabetes; baseline CD34⁺ levels; baseline CXCR4⁺ levels; and positive stress test results.