Table 1. Baseline Characteristics of Phase 2 Participants.
| Variable | Patients, No. (%) | |||||||
|---|---|---|---|---|---|---|---|---|
| Total (N = 292) | Site | Acute | ||||||
| Penn (n = 92) | Vand (n = 97) | Rush (n = 103) | Combination Therapy | Monotherapy | ||||
| Maintained (n = 85) | Withdrawn (n = 70) | Maintained (n = 68) | Withdrawn (n = 69) | |||||
| HRSD score, mean (SD)a | 5.6 (4.1) | 4.6 (3.8) | 5.7 (3.6) | 6.6 (4.3) | 5.8 (4.0) | 5.4 (3.9) | 5.4 (4.0) | 6.0 (4.4) |
| Maleb | 121 (41) | 52 (57) | 38 (39) | 31 (30) | 37 (44) | 29 (41) | 29 (43) | 26 (38) |
| Age, mean (SD), yb | 45.1 (12.9) | 47.5 (14.2) | 45.9 (11.8) | 42.0 (12.2) | 45.6 (13.0) | 43.9 (11.8) | 45.3 (12.6) | 45.6 (14.3) |
| White raceb | 256 (88) | 81 (88) | 91 (94) | 84 (82) | 72 (85) | 60 (86) | 63 (93) | 61 (90) |
| Hispanic ethnicityb | 16 (5) | 4 (4) | 3 (3) | 9 (9) | 7 (8) | 5 (7) | 1 (1) | 3 (4) |
| College graduateb | 176 (60) | 64 (70) | 51 (53) | 61 (59) | 53 (62) | 48 (69) | 38 (56) | 37 (54) |
| Income <$40 000/yb | 168 (58) | 49 (53) | 63 (65) | 56 (54) | 54 (64) | 42 (60) | 35 (51) | 37 (54) |
| Married or cohabitatingb | 113 (39) | 32 (55) | 39 (40) | 42 (41) | 32 (38) | 27 (39) | 27 (40) | 27 (40) |
| MDDb | ||||||||
| Chronic | 109 (37) | 34 (37) | 57 (59) | 18 (17) | 30 (35) | 22 (31) | 34 (50) | 23 (34) |
| Recurrent | 249 (85) | 77 (84) | 85 (88) | 87 (84) | 71 (84) | 62 (89) | 56 (82) | 60 (88) |
| Age at onset, mean (SD), yb | 24.6 (13.4) | 23.3 (14.5) | 24.5 (13.7) | 26.1 (11.8) | 23.8 (12.9) | 27.2 (14.4) | 23.9 (11.4) | 23.8 (14.6) |
| Previous episodes, No., mean (SD)b | 8.8 (19.3) | 8.1 (14.2) | 3.9 (7.4) | 14.5 (28.7) | 9.2 (20.0) | 4.8 (5.2) | 11.8 (26.1) | 9.1 (19.5) |
| Melancholicb | 114 (39) | 23 (25) | 47 (48) | 44 (43) | 34 (40) | 27 (39) | 21 (31) | 32 (47) |
| Atypicalb | 63 (22) | 18 (20) | 27 (28) | 18 (17) | 16 (19) | 18 (26) | 13 (19) | 16 (24) |
| Comorbid disorderc | ||||||||
| Axis I | 131 (45) | 29 (32) | 51 (53) | 51 (50) | 40 (47) | 28 (40) | 33 (49) | 30 (44) |
| Axis IIb | 137 (47) | 25 (27) | 55 (57) | 57 (55) | 37 (44) | 36 (51) | 32 (47) | 32 (47) |
Abbreviations: HRSD, Hamilton Rating Scale for Depression; MDD, major depressive disorder; Penn, University of Pennsylvania; Rush, Rush University; Vand, Vanderbilt University.
a
Measured at time of reassignment to phase 2 treatment condition.
b
Measured at intake before assignment to phase 1 treatment condition.
c
Identified using the DSM-IV.