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. 2019 Dec 3;7:823. doi: 10.3389/fchem.2019.00823

Figure 3.

Figure 3

Amino Acid composition of human galectins' CBS based on a topological analysis (Gal-12C excluded). (A) Probability graph for each topological position. Each residue is colored by its physicochemical properties. The protein topology naming corresponds to the piece of secondary structure under study, preceded by a number which indicates the relative position of each particular residue in that piece of secondary structure (e.g., “5-S2” corresponds to the position no. “5” of the “S2” β-strand). (B) Tridimensional representation of the Gal-9N, with the main residues of the CBS surface, highlighted as yellow (most conserved) or purple (least conserved). Hexasaccharide molecule is depicted with red lines and its monosaccharide units named with letters Z-Y-A-B-C-D. (C) Residue comparison along S4-S6 β-strands. (D) Individual contribution per monosaccharide to the total Binding Energy, calculated with the General Born method (Guardia et al., 2011). “Reprinted (adapted) with permission from Guardia et al. (2011). Copyright (2011) American Chemical Society”.