Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 3;7:823. doi: 10.3389/fchem.2019.00823

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Modenutti, Capurro, Di Lella and Martí.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Solvent structure of several human galectins. (A) Apo X-rays superimposition showing highly ordered crystallographic water molecules in the CBS. Color code is cyan for Gal-1 (1w6n-B), magenta for Gal-3 (3zsm-A), green for Gal-7 (4gal-A), orange for Gal-8N (3apb-B), and yellow for Gal-9C (3nv1-A). (B) Detail of Gal-1 (1w6o-A) in complex with lactose, showing the main polar residues and the Hydrogen bond network (dotted lines) established with the ligand. (C) Superimposition of A and B, showing that a clear displacement of water molecules is needed for binding to proceed.