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. 2019 Dec 3;7:823. doi: 10.3389/fchem.2019.00823

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Copyright © 2019 Modenutti, Capurro, Di Lella and Martí.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Galectins in complex with carbohydrate-derived monovalent inhibitors. (A) Thiodigalactoside “TD139” superimposed complexes of Gal-3 (magenta, PDB id: 5h9p) and Gal-7 (green, PDB id: 5h9q) (B) Taloside inhibitors superimposed complexes. Gal-1 and methyl 2-O-acetyl-3-O-toluoyl-beta-D-talopyranoside (cyan, PDB id: 3T2T), Gal-3 and methyl 3-deoxy-2-O-toluoyl-3-N-toluoyl-beta-D-talopyranoside (magenta, PDB id: 3T1M).