Table 2.
Baseline PRO scores
| PRO measures | Baseline, mean ± SD | ||
|---|---|---|---|
| PBO, n = 221 | UPA 15 mg, n = 221 | UPA 30 mg, n = 219 | |
| PtGA (mm) | 60.3 ± 20.5 | 63.1 ± 21.9 | 62.8 ± 20.3 |
| Pain VAS (mm) | 61.5 ± 20.8 | 64.1 ± 19.5 | 64.0 ± 19.8 |
| HAQ-DI | 1.4 ± 0.6 | 1.5 ± 0.6 | 1.5 ± 0.6 |
| FACIT-F | 28.3 ± 11.5 | 28.1 ± 11.1 | 27.5 ± 12.6 |
| SF-36 component scores | |||
| PCS | 33.1 ± 7.7 | 33.4 ± 7.4 | 32.6 ± 7.9 |
| MCS | 46.5 ± 11.7 | 45.9 ± 10.9 | 46.1 ± 12.0 |
| SF-36 domainsa | |||
| PF | 33.3 ± 9.4 | 33.5 ± 8.8 | 32.9 ± 9.7 |
| RP | 35.4 ± 8.1 | 35.5 ± 8.5 | 34.7 ± 8.9 |
| BP | 35.3 ± 6.9 | 35.5 ± 6.4 | 34.6 ± 6.8 |
| GH | 39.2 ± 9.0 | 38.9 ± 8.1 | 39.1 ± 9.4 |
| VT | 41.8 ± 9.0 | 41.5 ± 9.0 | 41.2 ± 10.0 |
| SF | 40.8 ± 10.8 | 40.6 ± 9.9 | 40.8 ± 11.0 |
| RE | 42.2 ± 11.9 | 41.1 ± 11.7 | 41.1 ± 11.9 |
| MH | 43.8 ± 10.7 | 44.1 ± 9.9 | 44.0 ± 11.5 |
| SF-6D Utility Index | 0.57 ± 0.1 | 0.57 ± 0.1 | 0.57 ± 0.1 |
| EQ-5D-5 L Index | 0.6 ± 0.2 | 0.6 ± 0.3 | 0.6 ± 0.3 |
| EQ-5D VAS (mm) | 51.4 ± 21.5 | 49.6 ± 21.3 | 49.0 ± 22.0 |
| AM joint stiffness | |||
| Duration (min) | 138.9 ± 214.0 | 152.4 ± 241.9 | 128.6 ± 156.0 |
| Severityb | 6.1 ± 2.2 | 6.1 ± 2.4 | 6.2 ± 2.2 |
| RA-WISc | 12.2 ± 6.1 | 12.9 ± 5.5 | 13.5 ± 6.5 |
AM morning, BP Bodily Pain, CI confidence interval, FACIT-F Functional Assessment of Chronic Illness Therapy-Fatigue, GH General Health, HAQ-DI Health Assessment Questionnaire-Disability Index, LSM least squares mean, MCS mental component summary, MH Mental Health, PBO placebo, PCS physical component summary, PF Physical Functioning, PRO patient-reported outcome, PtGA Patient’s Global Assessment of Disease Activity, RA-WIS Work Instability Scale for RA, RE Role-Emotional, RP Role-Physical, SD standard deviation, SF Social Functioning, SF-36 Short Form 36 Health Survey, UPA upadacitinib, VAS visual analogue scale, VT Vitality
aThe baseline values and LSM changes for SF-36 domains were transformed based on the mean and standard deviation of the 1998 general US population
bAssessed on a numeric scale of 1 to 10, with 10 being the worst level
cCalculated only for employed patients