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Effect of linolenic acid on the bupivacaine concentration–response curves in endothelium-intact aortae without (A; N = 6) or with (B; N = 7) Nω-nitro-l-arginine methyl ester (l-NAME) and in endothelium-denuded aortae (C; N = 7). Data are shown as mean ± standard deviation and expressed as the percentage of maximal contraction induced by isotonic 60 mM KCl. N indicates the number of isolated rat aortae. *P < .01 and † P < .001 versus control or l-NAME alone.
