Table 2.

Potential Biomarkers of EVs for Cancer Diagnostic Application.

Type	Protein Biomarker	Nucleic Acids	Long Noncoding RNA
Breast	HER2, CD82, ER, CD24, Ki67, TGF-β	miR-10b, miR-21, miR-145, miR-1246, miR-105, miR-222, and miR-200c	N/A
Lung (non-small cell lung cancer)	EFGR, MET, PIK2CA, ALK, KRAS, MAP2K1, HER2, BRAF, AKT1, CD151, CD171, and tetra-spannin 8, CD91, CD317, ECM1, LRG1	7b-5p, let-7e-5p, miR-23a-3p, miR-486-5p	lncRNA GAS5
Ovarian	HER2, TrKB, CD24, EpCAM	miR-375, miR-1307, miR-21, miR-200b, miR-100, miR-320, miR-141, miR-125b, miR-1246, and miR-93, miR-30a-5p, miR-145, miR25, miR148a, miR-101	N/A
Prostate	N/A	miR-1246, GATA2, miR-141, miR-375	SAP30L-AS1, SChLAP1
Pancreatic	GPC1, MIF, EGFR, Glypican-1, ZIP4, PD-L1, CD104, Epcam	miR-122-5p, miR-125b-5p, miR-1192-5p, miR-193b-3p, miR-221-3p and miR-27b-3p	N/A
Bladder	N/A	miR-148b-3p, miR-141, miR-27a-3p, miR-100, miR-92a, miR-99a, miR-93, miR-940, miR-375, miR-146a-5p	PCAT-1, SPRY4-IT1, UBC1 and SNHG16
Melanoma	PD-L1, CSPG4+	N/A	N/A
Brain (glioblastoma multiforme)	EGFR, EFGRvIII	miR-301a, miR-182-5p, miR-328-3p, miR-339-5p, miR-340-5p, miR-485-3p, miR-486-5p and miR-543, miR-22, miR-222	lncRNAs HOTAIR

Abbreviation: N/A, not applied.