Table 1.
Characteristics of the study population according to ischemic stroke status
| Variables | Proband (Ischemic stroke cases, n = 55) |
Sibling (ischemic stroke-free controls, n = 55) |
P value |
|---|---|---|---|
| Age (years), mean (SD) | 60.055 (7.578) | 59.655 (8.044) | 0.262 |
| Male (%) | 37 (67.273) | 30 (54.545) | 0.127 |
| Primary school or higher (%) | 27 (51.923) | 25 (48.077) | 0.683 |
| Marriage (%) | 47 (90.385) | 48 (92.308) | 0.564 |
| Smoking (%) | 31 (59.615) | 30 (57.692) | 0.808 |
| Drinking (%) | 27 (52.941) | 25 (49.020) | 0.637 |
| Diabetes (%) | 20 (36.363) | 11 (20.000) | 0.020 |
| Hypertension (%) | 48 (87.273) | 41 (74.545) | 0.071 |
| TC (mmol/L) * | 3.080 (2.160–3.910) | 3.175 (2.270–3.720) | 0.850 |
| TG (mmol/L) * | 1.190 (0.770–1.950) | 1.095 (0.770–1.930) | 0.294 |
| HDL (mmol/L) * | 0.880 (0.670–1.040) | 0.840 (0.680–1.120) | 0.973 |
| LDL (mmol/L) * | 2.050 (1.340–2.930) | 1.920 (1.510–2.680) | 0.806 |
| BMI (kg/m2), mean (SD) | 26.531 (3.527) | 26.309 (3.655) | 0.694 |
| baPWV (cm/s), mean (SD) | 1779.679 (344.664) | 1710.604 (328.646) | 0.230 |
| cIMT (mm), mean (SD) | 0.743 (0.122) | 0.695 (0.084) | 0.002 |
| ABI, mean (SD) | 1.052 (0.140) | 1.112 (0.087) | 0.004 |
| Methylation level (%) | |||
| cg02494239 (ABCG1) | |||
| Mean (SD) | 89.835 (10.900) | 88.236 (12.916) | 0.111 |
| Median (interquartile range) | 93.660 (92.780–94.240) | 93.260 (92.210–93.780) | 0.022 |
| Range (minimum–maximum) | 46.860–95.930 | 40.180–95.220 | |
| cg06500161 (ABCG1) | |||
| Mean (SD) | 87.891 (4.261) | 87.245 (4.364) | 0.292 |
| Median (IQR) | 88.475 (85.470–91.270) | 88.325 (85.330–89.590) | 0.436 |
| Range (minimum–maximum) | 76.460–96.040 | 70.080–95.635 | |
| cg14123992 (APOE) | |||
| Mean (SD) | 83.177 (4.491) | 82.824 (2.787) | 0.635 |
| Median (IQR) | 84.200 (82.12–85.19) | 83.530 (81.760–85.000) | 0.105 |
| Range (minimum–maximum) | 54.450–86.660 | 73.140–86.400 | |
TC total cholesterol, TG triglyceride, HDL high-density lipoprotein, LDL low-density lipoprotein, BMI body mass index, ABI ankle–brachial index, baPWV brachial–ankle pulse wave velocity, cIMT carotid intima–media thickness, ABI ankle–brachial index, ABCG1 ATP–binding cassette G1 gene, APOE apolipoprotein E gene, SD standard deviation, IQR interquartile range
*These quantitative variables are given as the median (interquartile range) because of their skewed distribution