Table 2.

Risks and risk differences of 30-day mortality categorized by marker positivity for soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2), in the derivation (N = 200) and validation (N = 200) cohorts. Standardized risks and risk differences are reported for the derivation cohort, adjusted for age, cirrhosis, immunocompromised state, septic shock at presentation, and mechanical ventilation at presentation. Crude risks and risk differences are reported for the validation cohort. The IL8 analysis is limited to immunocompetent patients (N = 105 in derivation cohort, N = 173 in validation cohort)

Marker and site	Number (%) of subjects above threshold	30-day mortality (95% CI) if below threshold	30-day mortality (95% CI) if above threshold	Risk difference of 30-day mortality (95% CI) if above threshold	p
sTNFR1 > 8861 pg/ml
Derivation	93 (46.5%)	30.4% (21.6, 39.2)	52.0% (42.3, 61.7)	21.6% (8.1, 35.2)	0.002
Validation	67 (33.5%)	21.1% (14.1, 28.0)	38.8% (27.1, 50.5)	17.8% (4.2, 31.3)	0.010
IL8 > 94 pg/ml
Derivation	57 (54.3%)	23.2% (11.8, 34.6)	40.9% (29.8, 52.0)	17.7% (1.6, 33.8)	0.031
Validation	68 (39.3%)	18.9% (11.9, 25.8)	44.1% (32.3, 55.9)	27.0% (13.2, 40.8)	< 0.001
Ang2 > 9761 pg/ml
Derivation	139 (69.5%)	25.8% (14.6, 37.1)	47.1% (39.3, 54.9)	21.3% (7.3, 35.3)	0.003
Validation	127 (63.5%)	19.2% (10.2, 28.2)	31.5% (23.4, 39.6)	12.3% (0.2, 24.4)	0.046