Table 2.
Univariate Cox regression model analysis for overall survival and cancer specific survival in nomogram cohort
| Characteristics | Overall Survival (OS) | Cancer Specific Survival (CSS) | ||
|---|---|---|---|---|
| HRa (95% CIb) | P-value | HR (95% CI) | P-value | |
| Age at diagnosis | ||||
| < 50 | 1 (Reference) | 1 (Reference) | ||
| 50–59 | 0.842 (0.632–1.121) | 0.239 | 0.782 (0.581–1.053) | 0.105 |
| 60–69 | 0.861 (0.654–1.134) | 0.288 | 0.746 (0.560–0.995) | 0.046 |
| 70–79 | 1.040 (0.803–1.349) | 0.765 | 0.876 (0.668–1.149) | 0.338 |
| 80–89 | 1.655 (1.276–2.146) | < 0.001 | 1.313 (1.000–1.725) | 0.050 |
| 90–100 | 2.447 (1.701–3.520) | < 0.001 | 1.983 (1.341–2.931) | 0.001 |
| Marital status | ||||
| Married | 1 (Reference) | 1 (Reference) | ||
| Single | 1.756 (1.528–2.017) | < 0.001 | 1.761 (1.511–2.052) | < 0.001 |
| Unknown | 1.614 (1.163–2.240) | 0.004 | 1.610 (1.122–2.312) | 0.010 |
| Race | ||||
| Black | 1 (Reference) | 1 (Reference) | ||
| White | 0.827 (0.678–1.008) | 0.060 | 0.809 (0.651–1.005) | 0.055 |
| Other | 0.624 (0.423–0.920) | 0.017 | 0.696 (0.464–1.044) | 0.079 |
| Sex | ||||
| Female | 1 (Reference) | 1 (Reference) | ||
| Male | 0.773 (0.677–0.883) | < 0.001 | 0.746 (0.644–0.864) | < 0.001 |
| Grade | ||||
| I | 1 (Reference) | 1 (Reference) | ||
| II | 0.943 (0.772–1.151) | 0.564 | 0.903 (0.727–1.121) | 0.354 |
| III | 0.825 (0.700–0.972) | 0.021 | 0.855 (0.715–1.023) | 0.086 |
| IV | 0.867 (0.769–0.976) | 0.019 | 0.905 (0.794–1.032) | 0.135 |
| T | ||||
| T1 | 1 (Reference) | 1(Reference) | ||
| T2 | 0.939 (0.760–1.161) | 0.562 | 0.947 (0.746–1.201) | 0.652 |
| T3 | 0.634 (0.501–0.802) | < 0.001 | 0.656 (0.504–0.853) | 0.002 |
| T4 | 1.473 (1.175–1.846) | 0.001 | 1.598 (1.246–2.050) | < 0.001 |
| Ta | 0.492 (0.181–1.334) | 0.163 | 0.486 (0.154–1.537) | 0.220 |
| Tis | 0.928 (0.453–1.902) | 0.839 | 0.576 (0.212–1.570) | 0.281 |
| N | ||||
| N0 | 1 (Reference) | 1 (Reference) | ||
| N1 | 1.654 (1.332–2.054) | < 0.001 | 1.810 (1.439–2.277) | < 0.001 |
| N2 | 1.707 (1.352–2.154) | < 0.001 | 1.933 (1.514–2.466) | < 0.001 |
| N3 | 2.608 (0.837–8.122) | 0.098 | 3.189 (1.023–9.941) | 0.046 |
| M | ||||
| M0 | 1 (Reference) | 1 (Reference) | ||
| M1 | 3.071 (2.509–3.758) | < 0.001 | 3.439 (2.786–4.246) | < 0.001 |
| RCc | ||||
| No | 1 (Reference) | 1 (Reference) | ||
| Yes | 0.400 (0.347–0.462) | < 0.001 | 0.389 (0.332–0.456) | < 0.001 |
| Metastasectomy | ||||
| No | 1 (Reference) | 1 (Reference) | ||
| Yes | 1.009 (0.775–1.315) | 0.944 | 0.991 (0.739–1.328) | 0.950 |
| Radiation | ||||
| No/unknown | 1 (Reference) | 1 (Reference) | ||
| Yes | 1.116 (0.946–1.316) | 0.192 | 1.132 (0.946–1.355) | 0.175 |
| Chemotherapy | ||||
| No/unknown | 1 (Reference) | 1 (Reference) | ||
| Yes | 0.824 (0.709–0.956) | 0.011 | 0.870 (0.740–1.023) | 0.092 |
| Size | ||||
| ≤ 6.5 cm | 1 (Reference) | 1 (Reference) | ||
| >6.5 cm | 1.736 (1.459–2.065) | < 0.001 | 1.806 (1.492–2.187) | < 0.001 |
| Unknown | 2.119 (1.815–2.474) | < 0.001 | 2.151 (1.812–2.555) | < 0.001 |
| LNRd | ||||
| 0 | 1 (Reference) | 1(Reference) | ||
| ≤ 0.0385 | 1.796 (0.842–3.830) | 0.130 | 1.730 (0.706–4.240) | 0.230 |
| >0.0385 | 3.307 (2.562–4.269) | < 0.001 | 4.164 (3.145–5.514) | < 0.001 |
| Unknown | 3.293(2.761–3.927) | < 0.001 | 3.805 (3.098–4.674) | < 0.001 |
aHR Hazard ratio
bCI Confidence interval
cRC Radical cystectomy
dLNR Lymph node ratio