Table 6.
Pharmacokinetic parameters
| Cmax/D | Tmax | AUC00-inf/D | t½ | Clearance | Vz | |
|---|---|---|---|---|---|---|
| ((ng/mL)/(mg/d)) | (h) | ((ng/mL*h)/(mg/d)) | (h) | (L/h) | (L) | |
| No. of Samples | 86 | 86 | 66 | 79 | 79 | 79 |
| Mean | 1.70 ± 1.18 | 2.07 ± 1.37 | 5.49 ± 2.75 | 1.98 ± 0.96 | 235 ± 149 | 644 ± 460 |
PK parameters (± SD). Means of all ages and dose levels
Cmax/D, maximum concentration normalized to 1 mg vorinostat per day; Tmax, time at maximum concentration; AUC0inf/D, area under the curve from 0 to infinitive normalized to 1 mg vorinostat per day; t½, half-life time of vorinostat; Vz, distribution volume