Table 3.

Association of age group and sex with loss of tibial cartilage volume (%/year) over 10.7 years

	Multivariable, β (95% CI)
	Medial	Lateral	Total tibia
Combined (n = 428)†
Age 50–60 years	Ref.	Ref.	Ref.
Age 60–70 years	0.16 (− 0.01 to 0.33)	0.07 (− 0.05 to 0.20)	0.11 (0.00 to 0.22)
Age 70–80 years	0.38 (0.08 to 0.67)	0.31 (0.08 to 0.53)	0.35 (0.16 to 0.54)
p for trend	0.006	0.012	< 0.001
Females (n = 211)‡
Age 50–60 years	Ref.	Ref.	Ref.
Age 60–70 years	0.26 (0.01 to 0.51)	0.11 (− 0.09 to 0.31)	0.17 (− 0.01 to 0.34)
Age 70–80 years	0.29 (− 0.19 to 0.76)	0.60 (0.22 to 0.98)	0.47 (0.13 to 0.80)
p for trend	0.042	0.007	0.004
Males (n = 217)‡
Age 50–60 years	Ref.	Ref.	Ref.
Age 60–70 years	0.09 (− 0.14 to 0.32)	0.02 (− 0.14 to 0.18)	0.05 (− 0.08 to 0.19)
Age 70–80 years	0.41 (0.03 to 0.79)	0.12 (− 0.15 to 0.39)	0.27 (0.05 to 0.49)
p for trend	0.053	0.449	0.035
Interaction with sex	− 0.04 (− 0.29 to 0.21)	− 0.17 (− 0.36 to 0.02)	− 0.10 (− 0.26 to 0.07)
p for interaction	0.778	0.084	0.241

^†Model 1: adjusted for sex, BMI, radiographic osteoarthritis, history of knee surgery and knee injury, physical activity and site-specific tibial cartilage volume at baseline

^‡Model 2: adjusted for BMI, radiographic osteoarthritis, history of knee surgery and knee injury, physical activity and site-specific tibial cartilage volume at baseline

Italicised data denotes statistically significant results