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. 2019 Aug 1;33(11):12164–12174. doi: 10.1096/fj.201900992R

Figure 4.

Figure 4

TREM2 knockout induces a shift from anti- to proinflammatory microglial activation state in AAV-SYN PD mice. AAV-GFP and AAV-SYN were unilaterally injected in the SN of WT and TREM2−/− mice. Mice were euthanized at 3 wk after virus injection. A, B) The expression of the proinflammatory marker TNF-α, iNOS (A), and anti-inflammatory marker ARG1, YM1 (B) in the ipsilateral SN were detected by real-time RT-PCR. *P < 0.05, **P < 0.01. C) Representative immunoblot and quantitative analysis of iNOS and ARG1 protein levels in the ipsilateral SN of WT and TREM2−/− mice. D) Representative immunoblot and quantitative analysis of p-STAT1 and p-STAT6 protein levels in the ipsilateral SN of WT and TREM2−/− mice. Data are presented as means ± sem, n = 4 animals/group. *P < 0.05, **P < 0.01 vs. WT + AAV-SYN group.