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Dose-dependent biphasic effects of MK on Hb and renal function. A) Changes in Hb following an oral dose of MK to CKD mice for 12 wk; means ± sem (n = 6–9). #P < 0.01, 5/6Nx-1.5 mpk vs. 5/6Nx-V; $P < 0.01, 5/6Nx-5 mpk vs. 5/6Nx-V; &P < 0.01, 5/6Nx-12.5 mpk vs. 5/6Nx-V; @P < 0.01, 5/6Nx-12.5 mpk vs. 5/6Nx-5 mpk. B) SCr, BUN, and urinary albumin/creatinine (ACR) levels were assessed. **P < 0.01 vs. 5/6Nx-V, #P < 0.01 vs. 5/6Nx-5 mpk (means ± sem; n = 6–9).
