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. 2019 Aug 26;33(11):12630–12643. doi: 10.1096/fj.201901087RR

Figure 4.

Figure 4

Fibrogenic effects of MK in TECs. A) Western blotting results of HIF-2α and HIF-1α expression in HK-2 cells treated with MK for 24 h. B, C) Effects of different doses of MK on α-SMA, collagen-I, and fibronectin mRNA (18 h) and protein (24 h) in HK-2 cells, as determined by real-time PCR (B) and Western blotting (B). Data are presented as means ± sem of 3 independent experiments. *P < 0.05, **P < 0.01 vs. vehicle. D) Western blotting results of α-SMA and collagen-I expression in HK-2 cells with MK treatment after HIF-2α siRNA interference (n = 3). GAPDH, glyceraldehyde 3-phosphate dehydrogenase.