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. 2019 Aug 26;33(11):12630–12643. doi: 10.1096/fj.201901087RR

Figure 7.

Figure 7

KLF5-dependent fibrogenic effects of high-dose MK in vivo. A) SCr and BUN levels were assessed. B) Representative changes in periodic scid-Schiff (PAS) staining. Scale bars, 100 μm. C) Representative changes in Masson staining. Scale bars, 50 μm. D, E) mRNA and protein (TGF-β1, α-SMA, collagen-I, and fibronectin) expression in the cortex of kidney, as determined by real-time PCR (D) and Western blotting (E). F) Representative immunohistochemical staining of TGF-β1. Scale bars, 50 μm. G) Representative immunofluorescence staining of collagen-I. Scale bars, 100 μm. GAPDH, glyceraldehyde 3-phosphate dehydrogenase. Data are presented as means ± sem of 4 mice. *P < 0.05, **P < 0.01 vs. Lv-NC.