TABLE 1.
Effect of the mitochondrial antioxidant MitoQ (200 µM) on general characteristics and metabolic parameters in CT-fed and HFD-fed rats
| Variable | CT | MitoQ | HFD | HFD+MitoQ |
|---|---|---|---|---|
| F I (g/d) | 22.3 ± 1.5 | 21.2 ± 1.6 | 18.6 ± 3.1* | 16.0 ± 2.1** |
| EI (kcal) | 64.7 ± 4.3 | 61.5 ± 4.0 | 100.4 ± 16.7** | 86.4 ± 11.3**,† |
| WI (ml/d) | 42.3 ± 7.1 | 48.0 ± 8.5 | 41.8 ± 5.6 | 43.9 ± 1.0 |
| EAT (g/cm tibia) | 1.1 ± 0.35 | 0.09 ± 0.21 | 3.18 ± 0.91** | 2.3 ± 0.54*,† |
| LAT (g/cm tibia) | 1.81 ± 0.49 | 1.76 ± 0.43 | 3.86 ± 0.81** | 2.77 ± 0.31††,‡ |
| MAT (g/cm tibia) | 0.85 ± 0.24 | 0.82 ± 0.12 | 1.84 ± 0.27* | 1.44 ± 0.17**,‡ |
| Adiposity index (%) | 4.6 ± 1.13 | 4.2 ± 0.83 | 9.1 ± 1.01** | 7.8 ± 0.85**,† |
| BAT (g/cm tibia) | 0.126 ± 0.03 | 0.136 ± 0.015 | 0.184 ± 0.05†† | 0.166 ± 0.012†† |
| Glucose (mg/dl) | 96.5 ± 11.4 | 99.6 ± 11.7 | 115.4 ± 6.3†† | 100.3 ± 10.34† |
| Insulin (pg/ml) | 90.8 ± 15.2 | 79.3 ± 20.4 | 272.3 ± 90.4** | 153.6 ± 36.8††,‡ |
| HOMA index | 3.3 ± 1.4 | 2.9 ± 1.3 | 10.3 ± 4.2** | 5.4 ± 2.5‡ |
| TG (mg/dl) | 78.6 ± 15.6 | 89.7 ± 18.3 | 146.8 ± 32.9†† | 129.0 ± 35.9†† |
| TC (mg/dl) | 66.5 ± 14.8 | 68.2 ± 10.5 | 68.1 ± 10.9 | 68.8 ± 8.4 |
BW, body weight; EI, energy intake; FI, food intake; LAT, lumbar adipose tissue; MAT, mesenteric adipose tissue; TG, triglyceride; TC, total cholesterol; WI, water intake. Data values represent the means ± sd of 8 animals. ††P < 0.05 compared with control group; *P < 0.01, **P < 0.001 compared with control group; †P 0.05, ‡P < 0.01 compared with HFD group.