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. 2019 Oct 5;33(11):13028–13039. doi: 10.1096/fj.201901590R

Figure 5.

Figure 5

Administration of 1000 mg/d of aspirin markedly alters CSF lipid mediator profiles after 30 d of treatment. CSF fluids were collected 30 d after administration of 81 or 1000 mg aspirin per day or placebo. Lipid mediators were extracted, identified, and quantified using lipid mediator profiling. Differences between CSF lipid mediator profiles of patients administered 81 (A) or 1000 (B) mg aspirin per day in comparison with those given placebo were evaluated using OPLS-DA. (Left panel) score plot; (right panel) loading plot. Mediators with a VIP score >1 are identified in red (placebo), green (1000 mg aspirin), or blue (81 mg aspirin) circles that denote the association with the placebo and aspirin group. Results are representative of n = 28 for patients in the 81-mg aspirin group, n = 27 patients in the 1000-mg aspirin group, and n = 34 patients in the placebo group. 2D, 2-dimensional.