Figure 11.

Deletion of P-selectin exacerbates visceral fat fibrosis in diet-induced obesity. A–C) Compared to WT mice fed a low fat diet (A), mice given an HFD for 10 consecutive weeks experienced collagen deposition in the epididymal fat (B), which was further exacerbated by deletion of P-selectin (C) (arrows indicate positive Sirius Red collagen staining). D) Bar graph ishows quantification of data from all experimental groups of mice. Values are means ± sem. Numbers at the bottom of bars are the number of mice studied in each group. In total, 2–5 tissue sections were studied in the VAT isolated from each mouse. LFD, low-fat diet; P-Sel, P-selectin.