Figure 12.

A, B) Deletion of P-selectin fails to improve glucose metabolism in HFD. Fasting blood glucose (A) and serum insulin (B) levels were measured at the end of the 16-wk feeding regimen. Serum insulin levels were measured by ELISA, and tail vein blood glucose was measured by glucometer. C, D) Intraperitoneal glucose tolerance test (C) and insulin tolerance test (D) were performed in mice after 16 wk of feeding, and blood glucose measurements were measured at the indicated time points. LFD, low-fat diet; NS, not significant; Psel, P-selectin. All data represent the means ± sem; n = 5–7. **P < 0.01 vs. control.