Palmitate-enriched triglycerides up-regulate LEIs in the VAT microcirculation. Gavage of a slurry of the modified triglycerides, tripalmitin and triolein, was used to isolate the effect of the relevant saturated FA palmitate and unsaturated FA oleate. Tripalmitin but not triolein up-regulates leukocyte rolling (A) and adhesion (B) in the VAT mesenteric postcapillary venules 90 min after gavage. Of note, the effect of triolein was comparable to that of the HFM used in this study. Values are means ± se. Numbers at the bottom of bars indicate the number of mice studied in each group. LFM, low-fat meal; ns, not sifnificant.