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. 2019 Aug 26;33(11):12477–12486. doi: 10.1096/fj.201901203R

Figure 1.

Figure 1

Plasma sulfur metabolites at 18 wk of age. Representative snapshots at plasma concentrations of total Hcy (A), total Cys (B), Cth (C), methionine (D), and SAM/SAH ratio (E) in mice at 18 wk of age. There were 8 study groups, as detailed in Supplemental Table S1, following study design showed in Supplemental Fig. S1. Briefly, beginning from wk 4 of age, mice were maintained on diets with normal (REG) or restricted (MRD) methionine content and received subcutaneous injections of either PBS vehicle or 10 mg/kg OT-58 3 times a week until the study end at wk 22 of age. A time course for plasma metabolite profiles reflecting entire duration of the study can be found in Supplemental Fig. S2. Significance is designaed by letters (a–d) at the top of the error bars. Columns that are significantly different from each other (P < 0.05) are indicated with different letters. Two letters indicate that the column is not significantly different from the single letter–designated columns.