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. 2019 Aug 26;33(11):12477–12486. doi: 10.1096/fj.201901203R

Figure 3.

Figure 3

Puzzle box test. A) Diagram of entry conditions in the puzzle box test for each trial during the 3-d testing period. B, C) Time to reach the goal box was similar in WT mice fed either diet and receiving vehicle (B) or OT-58 (C). D) I278T mice receiving vehicle and fed the REG diet were significantly cognitively impaired compared with the ones fed the MRD diet, as indicated by the longer time to reach goal box. E) However, I278T injected with OT-58 and fed the REG diet performed similarly as controls or I278T mice fed the MRD diet. Solid lines with filled symbols and dashed lines with open symbols designate mice fed the REG and MRD diets, respectively. Data points in all plots represent mean values, and error bars show sd. ***P < 0.001.