Figure 5.

Surfen treatment inhibits F98 tumor growth and progression as determined by MRI analysis. A) MRI demonstrates reduced tumor volume in surfen-treated animals at 7-d time point. T2* images processed from gradient echo MRI indicate significantly enhanced hemorrhage or iron deposition within untreated tumors across all time points. Representative images shown from identical slices within the brain. B) T2* histograms comparing treated and control tumor T2* values indicating decreased blood accumulation and necrosis in treated animals. C) Quantification of tumor volumes over 21 d after inoculation. D) Representative H&E staining of control and surfen-treated tumor tissue showing necrosis (white dotted lines) and cellular pseudopalisades (blue lines). Error bars represent means ± sd. *P < 0.05, Student’s t test.