Figure 7.

Effect of CoQ₁₀ on Tac-induced oxidative stress and apoptosis in a rat model. Representative images and quantification of immunopositivity for 8-OHdG (A–D, N) and 4-HHE (E–H, O) and results of the TUNEL assay (I–L, P) in rat kidney tissue. The high 8-OHdG and 4-HHE immunoreactivity induced by Tac was decreased by coadministration of CoQ10. M) Daily urinary 8-OHdG excretion. Tac-induced 8-OHdG excretion was reduced by CoQ₁₀ coadministration. Arrowheads indicate TUNEL-positive cells. Scale bars, 50 µm. Data represent means ± se (n = 8). One-way ANOVA was used to analyze the data. ^&P < 0.05 vs. Vh group; ^$P < 0.05 vs. CoQ₁₀ groups; ^#P < 0.05 vs. Tac group.