Figure 1.

A–D) Fluorescence images (A, C) and radioactivity images (B, D) of pancreatic sections (10 µm thick) from an MIP-GFP mouse, acquired using an image analyzer. Images were obtained from a single pancreatic section after 1000 times the amount of nonradioactive exendin (9–39) was administered in advance to block the uptake of [¹¹¹In]-Ex4 . The pancreas was harvested 60 min after the injection of [¹¹¹In]-Ex4 (2.0 MBq). Scale bars, 5 mm. E) Fluorescent and radioactive signal intensities were evaluated from the respective images for 9 pancreatic sections. A strong correlation was observed between fluorescent and radioactive signal intensity (r = 0.94).