Figure 6.

SMAD5-AS1 inhibition and miR-106a-5p overexpression can both attenuate NPC tumorigenesis. The nude mice used for following assays were injected with cells after treatment of empty vector, miR-106a-5p inhibitor, siRNA SMAD5-AS1, or miR-106a-5p mimic. A) Expression of SMAD5-AS1, miR-106a-5p, and SMAD5 in nude mice after different treatments. B) Tumor growth curve of nude mice after different treatments. Measurement data were expressed as means ± sd. Comparisons among multiple groups were analyzed by 1-way ANOVA, followed by Tukey’s post hoc test. Comparisons among multiple groups at different time points were analyzed via repeated measurement ANOVA, followed by Tukey’s post hoc test; n = 12. *P < 0.05 vs. the NC group.