Figure 3.
Effect of EPA supplementation on UVR-induced epidermal expression of lipid mediators. Epidermal lipids were measured 72 h after UVR exposure (3× MED), before and after 10-wk supplementation with EPA. A) Differences caused by EPA are shown in a metabolic map showing relative changes (log2 fold change) from unsupplemented skin. B) Selected lipid species affected by EPA (means ± sem, n = 12 volunteers). $P < 0.05; $$P < 0.001 presupplementation vs. postsupplementation at each time point. ALEA, alphalinolenoyl ethanolamine; DGLEA, dihomogammalinolenoyl ethanolamine; DHET, dihydroxyeicosatrienoic acid; DiHDPA, dihydroxydocosapentaenoic acid; DiHETE, dihydroxyeicosatetraenoic acid; DiHOME, dihydroxyoctadecenoic acid; DPEA, docosapentaenoyl ethanolamine; EET, epoxyeicosatrienoic acid; EpDPE, epoxydocosapentaenoic acid; EpOME, epoxyoctadecenoic acid; HETrE, hydroxyeicosatrienoic acid; HOTrE, hydroxyoctadecatrienoic acid; HPEA, heptadecanoyl ethanolamine; HX, hepoxilin; LEA, linoleoyl ethanolamine; LT, leukotriene; MEA, myristoyl ethanolamine; OEA, oleoyl ethanolamine; PDEA, pentadecanoyl ethanolamine; PEA, palmitoyl ethanolamine; PLEA, palmitoleoyl ethanolamine; SEA, stearoyl ethanolamine; t-EKODE, trans-epoxyketooctadecenoic acid; TX, thromboxane.