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. 2019 Jul 30;33(11):11706–11720. doi: 10.1096/fj.201900698R

Figure 5.

Figure 5

Effects of SHP2 deletion in myeloid cells on the inflammatory cell infiltration into lungs and airway hyperreactivity. Mice with the indicated genotypes were sensitized and subsequently challenged with OVA; 24 h after the final OVA challenge, mice were subjected to preparation of BALFs for inflammatory cell counting and classification (A), paraffin-embedded sections, H&E staining, and CCR3 immunostaining (B), and examination of methacholine-provoked airway hyperrreactivity (C) (n = 6). +P < 0.05; ++P < 0.01 vs. SHP2f/f mice challenged with NS; *P < 0.05; **P < 0.01 vs. SHP2f/f mice challenged with OVA. Square frames define the magnified regions.