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. 2019 Jul 30;33(11):11706–11720. doi: 10.1096/fj.201900698R

Figure 6.

Figure 6

Effects of overexpression of dnRhoA on SHP2 deletion–resultant inflammatory cell infiltration into lungs and airway hyperreactivity. Mice with the indicated genotypes were sensitized and subsequently challenged with OVA; 24 h after the last OVA challenge, mice were subjected to preparation of BALFs for inflammatory cell counting and classification (A), paraffin-embedded sections, H&E staining, and CCR3 immunostaining (B), examination of methacholine-provoked airway hyperreactivity (C) (n = 6). Square frames define the magnified regions. +P < 0.05; ++P < 0.01 vs. dnRhoA+/−;SHP2f/+ mice challenged with NS; **P < 0.01 vs. dnRhoA+/−;SHP2f/+ mice challenged with OVA; ‡P < 0.01 vs. LysM-Cre;dnRhoA+/− or LysM-Cre;SHP2f/+ mice challenged with OVA.