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. 2019 Jul 30;33(11):11706–11720. doi: 10.1096/fj.201900698R

TABLE 1.

Genetically modified mice

Genotype Description
LysM-Cre;SHP2f/f Two-copy deletion of SHP2 in myeloid cells
LysM-Cre;dnRhoA+/− Overexpression of 1-copy dominant-negative form of RhoA in myeloid cells
LysM-Cre;SHP2flox/+;dnRhoA+/− One-copy deletion of SHP2 and overexpression of 1-copy dominant-negative form of RhoA in myeloid cells
LysM-Cre;caRhoA+/− Overexpression of 1-copy constitutively active form of RhoA in myeloid cells
LysM-Cre;SHP2f/f;caRhoA+/− Two-copy deletion of SHP2 and overexpression of 1-copy constitutively active form of RhoA in myeloid cells