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The mechanisms of acetylation and deacetylation on the ε-amine group of lysine. A) Enzymatic acetylation catalyzed by KATs. B) Nonenzymatic acetylation with acetyl-CoA in mitochondrial matrix (pH 7.9–8.0 and acetyl-CoA 0.1–1.5 mM). C) Deacetylation mediated by Zn2+-dependent KDACs. D) Deacetylation mediated by NAD+-dependent SIRTs. SH, sulfydryl.
