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Sin3a depletion results in a decrease of dimethylation of histone H3 lysine 9. Immunocytochemical detection of histone marks for transcription repression (H3K9me2, H3K9me3, and H3K27me3) and transcription activation (H3K4me3) in Sin3a-depleted morulae (n = 3 pools of 5–10 embryos/group. *P < 0.05. The signal intensity of H3K9me2 (A, B) was reduced significantly in KD embryos, whereas no change was found for H3K9me3 (C), H3K4me3 (D), and H3K27me3 (E). Scale bar, 25 μm.
