. 2019 Dec 6;2(12):e1916953. doi: 10.1001/jamanetworkopen.2019.16953

Table 2. Best Combination Models of MicroRNAs to Detect Diffuse Glioma in Training Set 1.

No. of miRNAs	Model Candidates	Training Set 1
No. of miRNAs	Model Candidates	Sensitivity (95% CI)	Specificity (95% CI)	Accuracy (95% CI)	AUC (95% CI)	P Value
1	(1.42387 × miR-1225-3p) − 10.2225	0.93 (0.88-0.98)	0.83 (0.77-0.88)	0.86 (0.82-0.90)	0.95 (0.93-0.97)	NA
2	(1.21875 × miR-1225-3p) + (1.62781 × miR-1227-5p) − 25.2598	0.90 (0.84-0.96)	0.97 (0.95-0.99)	0.95 (0.92-0.97)	0.97 (0.96-0.99)	.006 (vs 1-miRNA model)
3	(2.09406 × miR-4763-3p) + (1.35369 × miR-1915-3p) + (–0.378659 × miR-3679-5p) − 32.11268	0.96 (0.92-1.00)	0.97 (0.95-0.97)	0.97 (0.95-0.99)	0.99 (0.99-1.00)	.01 (vs 2-miRNA model)
4	(1.78027 × miR-4763-3p) + (1.24861 × miR-1915-3p) + (–0.352535 × miR-3679-5p) + (0.295729 × miR-6729-3p) −30.12238	0.96 (0.92-1.00)	0.98 (0.96-1.00)	0.97 (0.95-0.99)	1.00 (0.99-1.00)	.15 (vs 3-miRNA model)
5	(2.03114 × miR-4763-3p) + (1.32272 × miR-1915-3p) + (–0.427725 × miR-3679-5p) + (0.494549 × miR-4741) + (–0.126557 × miR-204-3p) −34.1707	0.96 (0.92-1.00)	1.00 (1.00-1.00)	0.99 (0.97-1.00)	0.99 (0.99-1.00)	.83 (vs 4-miRNA model)

Abbreviations: AUC, area under the receiver operating characteristic curve; miRNAs, microRNAs; NA, not applicable.