Table 3. Between-Group Analysis of Main Outcome Measures in All Cases.
| Outcome | Intramuscular Administration | Intranasal Administration | Intervention Effect (95% CI) |
|---|---|---|---|
| Secondary naloxone, No. (%) | 0.35 (0.15-0.66)a | ||
| Yes | 8 (8.6) | 24 (23.1) | |
| No | 85 (91.4) | 80 (76.9) | |
| Time to GCS score ≥13, min | 1.65 (1.21-2.25)b | ||
| No.c | 86 | 91 | |
| Median (95% CI) | 8.0 (6.8-9.2) | 15.0 (13.9-16.1) | |
| Time to RR ≥10, min | 1.81 (1.28-2.56)b | ||
| No.c | 77 | 93 | |
| Median (95% CI) | 8.0 (6.1-9.9) | 17.0 (14.1-19.9) |
Abbreviations: GCS, Glasgow Coma Scale (score range: 3-15, with the highest score indicating normal responses); RR, respiratory rate.
a
Odds ratio and 95% CI for dichotomized outcomes.
b
Hazard ratio for time-to-event outcomes.
c
Some data were missing for these outcomes and were treated as censored observations.