Table 3.
The Pharmacokinetic Parameters of Esketamine and S-Norketamine in Different Genders (Esketamine Group)
| Parameters | Male (N=8) | Female (N=8) | P | |
|---|---|---|---|---|
| Esketamine | Tmax (min) | 1.18 (0.32–1.25) | 1.15 (0.28–1.20) | 0.166a |
| Cmax (ng/mL) | 2885.90±3726.90 | 1669.40±926.10 | 0.465b | |
| AUC0-t (h·ng/mL) | 480.90±86.60 | 402.80±68.40 | 0.062b | |
| AUC0-∞(h·ng/mL) | 512.60±91.80 | 437.80±66.30 | 0.086b | |
| CL (mL/min/kg) | 16.70±3.10 | 19.40±2.70 | 0.088 b | |
| t1/2 (min) | 243.00±77.30 | 332.00±124.60 | 0.125 b | |
| S-norketamine | Tmax (min) | 20.18 (10.15–20.22) | 20.16 (10.15–20.20) | 0.488a |
| Cmax (ng/mL) | 134.50±33.60 | 124.90±24.80 | 0.583 b | |
| AUC0-t (h·ng/mL) | 862.90 ±235.60 | 666.40 ±167.40 | 0.118 b | |
| AUC0-∞(h·ng/mL) | 1003.00 ±295.80 | 720.10 ±92.70 | 0.228 b | |
| CL (mL/min/kg) | 9.20±3.90 | 11.00±2.50 | 0.227 b | |
| t1/2 (min) | 477.80±115.60 | 566.00±107.20 | 0.081 b | |
Notes: Values are presented as mean ± SD, except Tmax, which is the median (range). a Statistics by Wilcoxon rank-sum test. b Statistics by Student’s t-test.
Abbreviations: Cmax, maximum plasma concentration; Tmax, time to reach Cmax; AUC0-∞, area under the plasma concentration–time curve from time zero to infinity; AUC0-t, area under the plasma concentration–time curve from zero until last measurable concentration; t1/2, elimination half-life; SD, standard deviation.