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Pathway to chronic rapamycin therapy in prostate cancer
Model: Chronic mTORC1 inhibition delays of PCa progression from active surveillance. mTORC1 and its downstream effectors promote tumor-cell growth (progression) in response to anabolic stimuli. Chronic inhibition of mTORC1 by drugs such as rapamycin would theoretically reduce the probability of conversion to Hi-grade PCa.
