Table 4.

One-pot method for the synthesis of pyrrolo[3,4-b]pyridin-5-one derivatives 1.^a

Entry	R1	R	Product	Yield, %
1	4-CH3O–C6H4(CH2)2	Cl	1a	60
2	H	Cl	1b	50
3	H	Br	1c	60
4	H	CH3	1d	59
5	CH3	Cl	1e	59
6	CH3	Br	1f	70
7	CH3	F	1g	54
8	CH3	CH3O	1h	55
9	CH3	CH3	1i	68
10	HO–(CH2)2	Cl	1j	50

^aReaction conditions: 1) 2 (3 mmol), amine 3 (9 mmol), AcOH (9 mmol), EtOH, reflux, 4 h. 2) HCl/AcOH, 5 mL/5 mL, reflux, 1 h.