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. Author manuscript; available in PMC: 2020 Nov 12.
Published in final edited form as: Biochemistry. 2019 Nov 4;58(45):4480–4493. doi: 10.1021/acs.biochem.9b00653

Figure 8. Interaction between K36-D29-S39.

Figure 8.

A. The wild-type (blue) and mutant HDAC8 (yellow) is illustrated. The S39-D29 interaction tethers loop 1 and maintains the orientation of K33 in the wild-type protein. S39E can interact with K36 but not with D29 and therefore K33 orientation is not maintained in the mutant. B-C. Distance plot showing the interaction between D29, K36 and S39 in (B) wild-type and (C) S39E mutant HDAC8. In wild type, S39 can interact with D29 directly while in S39E, mutant residue S39E and D29 are beyond interacting distance (green).